Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.

Abstract

In order to detect epitope-specific CD4+ T cells in mycobacterial or viral infections in the context of human class II major histocompatibility complex protein human leukocyte antigen (HLA)-DR3, two HLA-DR3 tetrameric molecules were successfully produced. One contained an immunodominant HLA-DR3-restricted T-cell epitope derived from the 65-kDa heat-shock… (More)

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@article{Bronke2005DirectEV, title={Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.}, author={Corine Bronke and Nanette M Palmer and Geertje H. A. Westerlaken and Mireille Toebes and Gijs M W van Schijndel and Veenu Purwaha and Krista E. van Meijgaarden and Ton N M Schumacher and Debbie van Baarle and Kiki Tesselaar and Annemieke Geluk}, journal={Human immunology}, year={2005}, volume={66 9}, pages={950-61} }