Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.

@article{Bronke2005DirectEV,
  title={Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.},
  author={Corine Bronke and Nanette M Palmer and Geertje H. A. Westerlaken and Mireille Toebes and Gijs M W van Schijndel and Veenu Purwaha and Krista E van Meijgaarden and Ton N M Schumacher and Debbie van Baarle and Kiki Tesselaar and Annemieke Geluk},
  journal={Human immunology},
  year={2005},
  volume={66 9},
  pages={950-61}
}
In order to detect epitope-specific CD4+ T cells in mycobacterial or viral infections in the context of human class II major histocompatibility complex protein human leukocyte antigen (HLA)-DR3, two HLA-DR3 tetrameric molecules were successfully produced. One contained an immunodominant HLA-DR3-restricted T-cell epitope derived from the 65-kDa heat-shock protein of Mycobacterium tuberculosis, peptide 1-13. For the other tetramer, we used an HLA-DR3-restricted T-cell epitope derived from… CONTINUE READING
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