Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template.

@article{Poon1999DirectET,
  title={Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template.},
  author={Leo Lit Man Poon and D C Pritlove and Ervin Fodor and George G. Brownlee},
  journal={Journal of virology},
  year={1999},
  volume={73 4},
  pages={3473-6}
}
The poly(A) tail of influenza virus mRNA is thought to be synthesized by reiterative copying of the U track near the 5' end of the virion RNA template. This has been widely accepted as a plausible hypothesis, but until now there has been no direct experimental evidence for it. Here, we report such direct evidence based on the fact that (i) replacing the U track with an A track directs synthesis of products with poly(U) tails, both in vitro and in vivo, and (ii) interrupting the U track… CONTINUE READING
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