Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

@article{Koch1994DirectET,
  title={Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.},
  author={Walter J Koch and Brian E. Hawes and Lee F. Allen and Robert J Lefkowitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 26},
  pages={12706-10}
}
Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). In several cell types, this appears to be dependent on the activation of p21ras (Ras). Which G-protein subunit(s) (G alpha or the G beta gamma complex) primarily is responsible for triggering this signaling pathway, however, is unclear. We have demonstrated previously that the carboxyl terminus of the beta-adrenergic receptor kinase, containing its G beta gamma-binding domain, is a… CONTINUE READING
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