Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease.

Abstract

HD is a progressive genetic neurological disorder, characterized by motor as well as cognitive impairments. The gene carrying the mutation causing Huntington's disease (HD) is not brain specific, and there is increasing evidence for peripheral, as well as brain pathology in this disorder. Here, we used in vivo and ex vivo techniques to assess the cardiac… (More)
DOI: 10.3233/JHD-2012-120004

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