Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats

  title={Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats},
  author={Carmelina Loguercio and Giuseppe D'Argenio and Massimo Delle Cave and Vittorio Cosenza and Nicola Della Valle and Gabriele Mazzacca and Camillo Del Vecchio Blanco},
  journal={Digestive Diseases and Sciences},
During inflammatory colitis in man and experimental animals, the production of free radicals increases. This study evaluated the histological pattern and biochemical parameters of oxidative damage during acute and chronic colitis induced by 2,4,-trinitrobenzenesulfonic acid + ethanol in rats. On the samples of scraped mucosa of six groups of rats, one not treated, one killed after 1 hr, and those killed one, two, four, and eight weeks after the induced-damage, we determined the histological and… CONTINUE READING
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