Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960

  title={Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960},
  author={Michael Worobey and Marlea Gemmel and Dirk E. Teuwen and Tamara S. Haselkorn and Kevin J. Kunstman and Michael Bunce and Jean-Jacques Muyembe and Jean-Marie Mpolesha Kabongo and Rapha{\"e}l Mbowa Kalengayi and Eric A. E. Van Marck and Marcus Thomas Pius Gilbert and Steven M. Wolinsky},
Human immunodeficiency virus type 1 (HIV-1) sequences that pre-date the recognition of AIDS are critical to defining the time of origin and the timescale of virus evolution. A viral sequence from 1959 (ZR59) is the oldest known HIV-1 infection. Other historically documented sequences, important calibration points to convert evolutionary distance into time, are lacking, however; ZR59 is the only one sampled before 1976. Here we report the amplification and characterization of viral sequences… CONTINUE READING
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