Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex.

@article{Liu2010DirectEF,
  title={Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex.},
  author={Zhong-wu Liu and Ugo Faraguna and Chiara Cirelli and Giulio Tononi and X B Gao},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 25},
  pages={8671-5}
}
Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex. By recording miniature EPSCs (mEPSCs) from frontal cortex slices of mice and rats that had been awake or asleep, we found that the frequency and amplitude of mEPSCs increased after waking and decreased after sleep, independent of time of day. Recovery sleep after deprivation also decreased… CONTINUE READING