Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ.

@article{Kay2000DirectEF,
  title={Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ.},
  author={Laurence Kay and Klaas Nicolay and B E Wieringa and V. Saks and Theo Wallimann},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 10},
  pages={6937-44}
}
The efficiency of stimulation of mitochondrial respiration in permeabilized muscle cells by ADP produced at different intracellular sites, e.g. cytosolic or mitochondrial intermembrane space, was evaluated in wild-type and creatine kinase (CK)-deficient mice. To activate respiration by endogenous production of ADP in permeabilized cells, ATP was added either alone or together with creatine. In cardiac fibers, while ATP alone activated respiration to half of the maximal rate, creatine plus ATP… CONTINUE READING
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