Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14

@article{Babaya2010DirectEF,
  title={Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14},
  author={Naru Babaya and Tomomi Fujisawa and Koji Nojima and Michiko Itoi-Babaya and Kaori Yamaji and K. Yamada and M. Kobayashi and Hironori Ueda and Yoshihisa Hiromine and Shinsuke Noso and H. Ikegami},
  journal={Diabetologia},
  year={2010},
  volume={53},
  pages={1362-1371}
}
Aims/hypothesisDiabetogenic loci for type 2 diabetes have been mapped to mouse chromosome (Chr) 11 and 14 in the Nagoya–Shibata–Yasuda (NSY) mouse, an animal model of type 2 diabetes. We aimed to obtain direct evidence of these genes on each chromosome and to clarify their function and interaction in conferring susceptibility to type 2 diabetes.MethodsWe established three consomic strains homozygous for diabetogenic NSY-Chr11, NSY-Chr14 or both on the control C3H background (C3H-11NSY, C3H… 

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