Direct evidence for spontaneous branch migration in antiparallel DNA Holliday junctions.

@article{Sha2000DirectEF,
  title={Direct evidence for spontaneous branch migration in antiparallel DNA Holliday junctions.},
  author={Ruojie Sha and Furong Liu and Nadrian C. Seeman},
  journal={Biochemistry},
  year={2000},
  volume={39 37},
  pages={11514-22}
}
The Holliday junction is a central intermediate in genetic recombination. It contains four strands of DNA that are paired into four double helical arms flanking a branch point. In naturally occurring Holliday junctions, the sequence flanking the branch point contains 2-fold (homologous) symmetry. As a consequence of this symmetry, the junction can undergo a conformational isomerization known as branch migration, which relocates the site of branching. In the absence of proteins and in the… CONTINUE READING

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