Direct evidence for local generation and release of angiotensin II in human vascular tissue.

@article{Mizuno1989DirectEF,
  title={Direct evidence for local generation and release of angiotensin II in human vascular tissue.},
  author={Kyoichi Mizuno and Momo Tani and Susumu Niimura and Shinji Hashimoto and Akinori Satoh and Kazuaki Shimamoto and Tadashi Inagami and Sōtarō Fukuchi},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={165 1},
  pages={457-63}
}
A direct measurement of both angiotensins I and II immunoreactive substances was made in the perfusate from isolated human umbilical vein perfused with Krebs-Ringer solution which was free of any component of the renin-angiotensin system. The identity of the immunoreactive peptides was confirmed as angiotensin I and angiotensin II by high-performance liquid… CONTINUE READING