Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.

@article{Schandel1994DirectEF,
  title={Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.},
  author={K A Schandel and D. Jenness},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 11},
  pages={7245-55}
}
When Saccharomyces cerevisiae a cells bind alpha-factor pheromone, the ligand is internalized and its binding sites are lost from the cell surface in a time-, energy-, and temperature-dependent manner. This report presents direct evidence for alpha-factor-induced internalization of cell surface receptors. First, membrane fractionation on Renografin density gradients indicated that the alpha-factor receptors were predominantly found in the plasma membrane peak before alpha-factor treatment and… CONTINUE READING

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