Direct evidence for in vivo hydroxyl radical generation in blood of mice after acute chromium (VI) intake

Although it is assumed from in vitro experiments that the hydroxyl radical (·OH) may be responsible for chromium(VI) toxicity / carcinogenicity, no electron spin resonance (ESR) evidence for the generation of ·OH in vivo has been reported. In this study, we have employed an ESR spin-trapping technique with 5,5-dimethylpyrroline-N-oxide (DMPO), a selective… CONTINUE READING