Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.

@article{Jiang1992DirectEF,
  title={Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.},
  author={H. Jiang and J. L. Colbran and S. Francis and J. Corbin},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 2},
  pages={
          1015-9
        }
}
Elevation of either cAMP or cGMP causes smooth muscle relaxation. Whether these effects are mediated through cAMP-dependent protein kinase (cAK), cGMP-dependent protein kinase (cGK), or both is unknown. Pig coronary arteries were treated with sodium nitroprusside (SNP) or atrial natriuretic factor (ANF), relaxants which elevate cGMP, and with isoproterenol or forskolin, relaxants which elevate cAMP. Incubation of the arteries with 10 microM SNP produced a 3.3-fold increase in cGMP without… Expand
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