Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.

@article{Mort1993DirectEF,
  title={Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.},
  author={John S. Mort and George R. Dodge and Peter J. Roughley and Janice J Liu and Stephen J. Finch and Gene Dipasquale and A. Robin Poole},
  journal={Matrix},
  year={1993},
  volume={13 2},
  pages={
          95-102
        }
}
When adult human articular cartilage was maintained in organ culture in the presence of interleukin 1 beta, increased destruction of the extracellular matrix was observed, as judged by increased type II collagen degradation in situ determined immunohistochemically and the increased release of proteoglycan into the culture medium. Concomitant with these changes was the increased release of latent metalloproteinases into the culture medium. Culture of cartilage in the presence of a… CONTINUE READING

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