Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium.

@article{Kim2015DirectEO,
  title={Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium.},
  author={P. Kim and M. Mahmoudi and X. Ge and Y. Matsuura and I. Toma and Scott Metzler and N. Kooreman and John Ramunas and C. Holbrook and M. McConnell and H. Blau and Phillip Harnish and E. Rulifson and P. Yang},
  journal={Circulation research},
  year={2015},
  volume={116 7},
  pages={
          e40-50
        }
}
  • P. Kim, M. Mahmoudi, +11 authors P. Yang
  • Published 2015
  • Biology, Medicine
  • Circulation research
  • RATIONALE The mechanism of functional restoration by stem cell therapy remains poorly understood. Novel manganese-enhanced MRI and bioluminescence reporter gene imaging were applied to follow myocardial viability and cell engraftment, respectively. Human-placenta-derived amniotic mesenchymal stem cells (AMCs) demonstrate unique immunoregulatory and precardiac properties. In this study, the restorative effects of 3 AMC-derived subpopulations were examined in a murine myocardial injury model: (1… CONTINUE READING
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