Direct estrogen receptor (ER) / HER family crosstalk mediating sensitivity to lumretuzumab and pertuzumab in ER+ breast cancer

@inproceedings{Collins2017DirectER,
  title={Direct estrogen receptor (ER) / HER family crosstalk mediating sensitivity to lumretuzumab and pertuzumab in ER+ breast cancer},
  author={Denis M. Collins and Wolfgang Jacob and Juan Miguel Cejalvo and Maurizio Ceppi and Ian M James and Max Hasmann and John P. A. Crown and Andr{\'e}s Cervantes and Martin Weisser and Birgit Bossenmaier},
  booktitle={PloS one},
  year={2017}
}
Bidirectional cross talk between members of the human epidermal growth factor family of receptors (HER) and the estrogen receptor (ER) is believed to underlie resistance mechanisms that develop in response to treatment with anti-HER agents and endocrine therapy. We investigated the interaction between HER2, HER3 and the ER in vitro using human embryonic kidney cells transfected with human HER2, HER3, and ERα. We also investigated the additive efficacy of combination regimens consisting of anti… CONTINUE READING
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