Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

@article{HaagLiautard2007DirectEO,
  title={Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila},
  author={Cathy Haag-Liautard and Mark Dorris and Xulio R Maside and Steven Macaskill and Daniel L. Halligan and Brian Charlesworth and Peter D. Keightley},
  journal={Nature},
  year={2007},
  volume={445},
  pages={82-85}
}
Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this can be used to date speciation events by assuming a molecular clock. The overall rate of occurrence of deleterious mutations in the genome each generation (U) appears in theories… CONTINUE READING
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