Direct electrochemistry of human, bovine and porcine cytochrome P450c17.

  title={Direct electrochemistry of human, bovine and porcine cytochrome P450c17.},
  author={Daniel L. Johnson and Alan James Conley and Lisandra L Martin},
  journal={Journal of molecular endocrinology},
  volume={36 2},
The direct electrochemistry of human, bovine and porcine cytochrome P450c17 (CYP17) has been examined on an edge-oriented pyrolytic graphite electrode. The recombinant protein was immobilized on an electrode modified with a surfactant to simulate the environment of a biological membrane, and hence physiological electron-transfer conditions. The P450 enzymes all retained 'electron-transfer' activity while immobilized at the electrode surface as assessed by the presence of catalytic signals under… CONTINUE READING
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