Direct electrochemical measurement of nitric oxide in vascular endothelium.

@article{Brovkovych1999DirectEM,
  title={Direct electrochemical measurement of nitric oxide in vascular endothelium.},
  author={Victor Brovkovych and Emilie Stolarczyk and Janez Oman and P Tomboulian and Tadeusz Malinski},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1999},
  volume={19 1-2},
  pages={135-43}
}
The endothelium plays a critical role in maintaining vascular tone by releasing vasoconstrictor and vasodilator substances. Endothelium-derived nitric oxide (NO) is a vasodilator rapidly inactivated by superoxide and by Fe(II) and Fe(III), all found in significant quantities in biological systems. Thus due to the short life of NO in tissue (t1/2 = 3-6 s… CONTINUE READING