Direct effects of tumor necrosis factor alpha (TNF-alpha) on murine skeletal muscle cell lines. Bimodal effects on protein metabolism.

@article{Alvarez2001DirectEO,
  title={Direct effects of tumor necrosis factor alpha (TNF-alpha) on murine skeletal muscle cell lines. Bimodal effects on protein metabolism.},
  author={Bel{\'e}n Alvarez and Lebris S Quinn and S{\'i}lvia Busquets and Francisco Javier L{\'o}pez-Soriano and Josep Maria Argil{\'e}s},
  journal={European cytokine network},
  year={2001},
  volume={12 3},
  pages={399-410}
}
Incubation of murine C2C12 myotubes with tumour necrosis factor-alpha (TNF-alpha) leads to significant changes in protein content and turnover, suggesting that the cytokine exerts direct effects in skeletal muscle. The effects of the cytokine on protein content show a clear bimodal behaviour. At low concentrations (1 U/ml or less), TNF-alpha decreases both total and myofibrillar protein content, while at relatively high concentrations (100 U/ml or more), the effects are opposite and TNF-alpha… CONTINUE READING

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