Direct effects of the anabolic/androgenic steroids, stanozolol and 17α-methyltestosterone, on benzodiazepine binding to the γ-aminobutyric acidA receptor

@article{Masonis1995DirectEO,
  title={Direct effects of the anabolic/androgenic steroids, stanozolol and 17$\alpha$-methyltestosterone, on benzodiazepine binding to the $\gamma$-aminobutyric acidA receptor},
  author={A. E. Tory Masonis and Michael P. McCarthy},
  journal={Neuroscience Letters},
  year={1995},
  volume={189},
  pages={35-38}
}
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44 Citations
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44 Citations

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The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference
Anabolic steroids induce region- and subunit-specific rapid modulation of GABA(A) receptor-mediated currents in the rat forebrain.
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It is reported that in prepubertal female rats, three commonly abused AAS induced rapid and reversible modulation of GABAergic currents in neurons of two brain regions known to be critical for the expression of reproductive behaviors: the ventromedial nucleus of the hypothalamus and the medial preoptic area.
Some rewarding effects of androgens may be mediated by actions of its 5α-reduced metabolite 3α-androstanediol
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Role of the α subunit in the modulation of GABAA receptors by anabolic androgenic steroids
The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference
Blockade of androgen or estrogen receptors reduces nandrolone's ability to modulate acute reward-related neurochemical effects of amphetamine in rat brain
Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
Estrous cycle variations in GABAA receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area
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