Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine.

@article{Zhang2007DirectEO,
  title={Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine.},
  author={Le-Feng Zhang and S. Peng and S. Wang and B. Li and Gang Han and Yan-sheng Dong},
  journal={Toxicology letters},
  year={2007},
  volume={170 2},
  pages={
          104-10
        }
}
Lead (Pb(2+)) exposure is related to increased blood pressure or hypertension of human or animals. Abnormal vascular relaxant responses of low level Pb(2+) exposed animals were reported by several studies. However, it is difficult to tell whether these effects were induced directly by Pb(2+) or not. In this study we hypothesized that Pb(2+) can directly affect the relaxation of vessels. Male Wistar rat aortae were removed and cultured in PMRI 1640 with 1 ppm Pb(2+) (4.8 microM lead acetate) for… Expand
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