Direct effects of ethane dimethanesulphonate on epididymal function in adult rats. An in vitro demonstration.

@article{Klinefelter1992DirectEO,
  title={Direct effects of ethane dimethanesulphonate on epididymal function in adult rats. An in vitro demonstration.},
  author={Gary Robert Klinefelter and Naomi L Roberts and Juan D. Suarez},
  journal={Journal of andrology},
  year={1992},
  volume={13 5},
  pages={
          409-21
        }
}
It was recently demonstrated that the Leydig cell toxicant ethane dimethanesulphonate (EDS) produces multiple effects on the epididymis after a single in vivo exposure. To determine whether any of the perturbations were mediated by a direct action of the compound, we used a novel system for the coculture of epididymal epithelial cells and sperm from the caput epididymidis. This system maintains the morphologic integrity and cell polarity of the epididymal epithelial cells before and during… CONTINUE READING

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