Direct effects of endotoxin on the endothelium: barrier function and injury.

@article{Bannerman1999DirectEO,
  title={Direct effects of endotoxin on the endothelium: barrier function and injury.},
  author={Douglas D. Bannerman and Simeon E. Goldblum},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1999},
  volume={79 10},
  pages={1181-99}
}
LPS directly disrupts EC barrier function in vitro and in vivo. This barrier dysfunction has been reported to occur in EC derived from both the macro- and microvasculature of varying species, including humans. Unlike other EC responses, LPS-induced loss of endothelial barrier function is protein-synthesis independent. In fact, protein synthesis inhibition enhances the LPS effect. The lipid A moiety is responsible for LPS-induced activation of the non-CD14-bearing EC, and agents that bind to and… CONTINUE READING