Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.

@article{Grimmsmann1998DirectEO,
  title={Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.},
  author={T Grimmsmann and Ingo Rustenbeck},
  journal={British journal of pharmacology},
  year={1998},
  volume={123 5},
  pages={781-8}
}
1. The direct effects of diazoxide on mitochondrial membrane potential, Ca2+ transport, oxygen consumption and ATP generation were investigated in mouse pancreatic B-cells and rat liver mitochondria. 2. Diazoxide, at concentrations commonly used to open adenosine 5'-triphosphate (ATP)-dependent K+-channels (K(ATP) channels) in pancreatic B-cells (100 to 1000 microM), decreased mitochondrial membrane potential in mouse intact perifused B-cells, as evidenced by an increase of rhodamine 123… CONTINUE READING
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