Direct effects of cyclosporin A and cyclophosphamide on differentiation of normal human myoblasts in culture.

@article{Hardiman1993DirectEO,
  title={Direct effects of cyclosporin A and cyclophosphamide on differentiation of normal human myoblasts in culture.},
  author={Orla Hardiman and Robert M. Sklar and R. H. Brown},
  journal={Neurology},
  year={1993},
  volume={43 7},
  pages={1432-4}
}
We examined the direct effects of the commonly used immunosuppressive agents cyclosporin A and cyclophosphamide on cultures of clonally derived aneural human myoblasts. When applied to cultures in doses reflecting the therapeutic dose in vivo, both cyclosporin A and cyclophosphamide had dose-related reproducible effects on myoblast fusion: fusion was enhanced by cyclophosphamide and inhibited by cyclosporin A. These findings indicate that immunosuppressive agents may have effects on muscle that… CONTINUE READING

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