Direct effects of corticotrophin on oral keratinocyte cell proliferation.

  title={Direct effects of corticotrophin on oral keratinocyte cell proliferation.},
  author={Supriya Kapas and Eleni Hagi-Pavli and Dean W. Brown and Vijay Chhajlani and Paula M Farthing},
  journal={European journal of biochemistry},
  volume={256 1},
Corticotropin is produced by keratinocytes and may have an immunoregulatory role in oral mucosa and skin. We have investigated its effects on a human oral keratinocyte cell line and shown that corticotropin, acting via its specific receptor, stimulates a dose-dependent increase in DNA synthesis and induces cell proliferation. When cells were incubated in the presence of increasing concentrations of corticotropin, there were significant increases in intracellular cAMP levels. Corticotropin… CONTINUE READING