Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.

@article{Tkach2011DirectEO,
  title={Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.},
  author={Alexey V. Tkach and Galina V. Shurin and Michael R. Shurin and Elena R. Kisin and Ashley R. Murray and S H Young and Alexander Star and Bengt Fadeel and Valerian E Kagan and Anna A. Shvedova},
  journal={ACS nano},
  year={2011},
  volume={5 7},
  pages={5755-62}
}
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic… CONTINUE READING

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