Direct effects of CO on cerebral energy metabolism in bloodless rats.

@article{Piantadosi1988DirectEO,
  title={Direct effects of CO on cerebral energy metabolism in bloodless rats.},
  author={Claude A. Piantadosi and P. A. Lee and Avis L. Sylvia},
  journal={Journal of applied physiology},
  year={1988},
  volume={65 2},
  pages={
          878-87
        }
}
Cerebrocortical b-cytochromes have been found to be sensitive to reduction in the presence of CO and O2 in vivo. CO-mediated cytochrome b reduction responses in "bloodless" rats were correlated in this study with changes in concentrations of high energy and glycolytic intermediates measured in cortex after rapid brain freezing. Cytochrome redox state and metabolite concentrations also were compared with cerebral blood flow (CBF) and cerebral metabolic rate for O2 (CMRo2) measured before and… 

Recovery of energy metabolism in rat brain after carbon monoxide hypoxia.

Analysis of data in anesthetized rats during CO exposure and recovery at either normobaric or hyperbaric O2 concentrations indicates that intracellular uptake of CO can impair cerebral energy metabolism, despite the elimination of HbCO from the blood.

Reversal of carbon monoxide-cytochrome c oxidase binding by hyperbaric oxygen in vivo.

It is indicated that CO binds to reduced cytochrome a3 in blood circulated rat cortex in CO hypoxia and this effect can be reversed by increasing dissolved arterial O2 content at 3 ATA.

Cerebrovascular effects of carbon monoxide.

Specific regions of the brain, such as central white matter, globus pallidus, and hippocampus, are selectively vulnerable to CO toxicity, but whether the mechanisms involved in selective injury differ from other forms of hypoxia-ischemia needs to be clarified.

Hyperbaric oxygenation affects rat brain function after carbon monoxide exposure.

The application of hyperbaric oxygenation (HBO2) has been recommended for correction of neurological injury in severely CO-poisoned patients. However, the mechanisms of HBO2 action on brain

The Vasorelaxation of Cerebral Arteries by Carbon Monoxide

Cerebral arteries are directly relaxed by CO and that this relaxation depends upon the activation of guanylyl cyclase and the opening of potassium channels, which are known to increase cerebral blood flow.

Metabolic Disorders as Consequences of Drug-Induced Energy Deficits

The human brain accounts for only 2% of the total body weight but requires more than 15% of the cardiac output. This clearly indicates that the metabolic rate of brain tissue is higher than that of

Fiber Optic Surface Fluorometry-Reflectometry Technique in the Renal Physiology of Rats

  • Y. ZurovskyJ. Sonn
  • Biology, Medicine
    Journal of basic and clinical physiology and pharmacology
  • 1992
It seems that optical techniques for monitoring fluorescence are suitable for localized, continuous and non-invasive recording of tissue mitochondrial NADH redox states under various conditions in the rat kidney.