Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.

@article{TakanoYamamoto1990DirectEO,
  title={Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.},
  author={Teruko Takano-Yamamoto and Gideon A. Rodan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 6},
  pages={
          2172-6
        }
}
High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally into rat femur trabecular bone. Sprague-Dawley rats weighing 150-160 g were ovariectomized (OVX) and 14 days later a polyethylene tube (1 mm in diameter) connected to an Alzet… CONTINUE READING

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