• DOI:10.1073/PNAS.87.6.2172
Corpus ID: 2999401

Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.

@article{TakanoYamamoto1990DirectEO,
  title={Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.},
  author={T. Takano-Yamamoto and G. Rodan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 6},
  pages={
          2172-6
        }
}

T. Takano-Yamamoto, G. Rodan

Published 1990

Chemistry, Medicine

Proceedings of the National Academy of Sciences of the United States of America

High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally into rat femur trabecular bone. Sprague-Dawley rats weighing 150-160 g were ovariectomized (OVX) and 14 days later a polyethylene tube (1 mm in diameter) connected to an Alzet… CONTINUE READING

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