Corpus ID: 24374038

Direct effect of metolazone on sodium-dependent transport across the renal brush border membrane.

@article{Kempson1983DirectEO,
  title={Direct effect of metolazone on sodium-dependent transport across the renal brush border membrane.},
  author={Stephen A. Kempson and Joseph C. Kowalski and Jules B. Puschett},
  journal={The Journal of laboratory and clinical medicine},
  year={1983},
  volume={101 2},
  pages={
          308-16
        }
}
Studies with clearance and micropuncture techniques indicate that metolazone inhibits transport of sodium and phosphate in the proximal tubule. The present study is focused on transport across the luminal BBM of the proximal tubule to determine whether metolazone has any direct effect on this initial step in transtubular reabsorption. Addition of metolazone (0.01 to 1.00 mM) to isolated renal BBM vesicles caused dose-dependent inhibition (30% to 70%) of the initial uphill phase of Na+ gradient… Expand
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