Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling.

@article{Singson1994DirectDT,
  title={Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling.},
  author={Andrew Singson and Michael W. Leviten and Anne G Bang and Xuequn Helen Hua and James W Posakony},
  journal={Genes & development},
  year={1994},
  volume={8 17},
  pages={
          2058-71
        }
}
In Drosophila imaginal discs, the spatially restricted activities of the achaete (ac) and scute (sc) proteins, which are transcriptional activators of the basic-helix-loop-helix class, define proneural clusters (PNCs) of potential sensory organ precursor (SOP) cells. Here, we report the identification of several genes that are direct downstream targets of ac-sc activation, as judged by the following criteria. The genes are expressed in the PNCs of the wing imaginal disc in an ac-sc-dependent… CONTINUE READING
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