Corpus ID: 38490610

Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy.

@article{Los1989DirectDO,
  title={Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy.},
  author={G. Los and P. Mutsaers and W. van der Vijgh and G. S. Baldew and P. D. de Graaf and J. Mcvie},
  journal={Cancer research},
  year={1989},
  volume={49 12},
  pages={
          3380-4
        }
}
Chemotherapy i.p. is increasingly being tested as a treatment modality for cancer limited to the peritoneal cavity. We have developed a rat tumor model in which penetration and distribution of cis-diamminedichloroplatinum(II) into intraperitoneal tumors have been studied. The platinum concentration in intraperitoneal tumor nodules, measured by two techniques, flameless atomic absorption spectroscopy and proton-induced X-ray emission, was always higher after i.p. treatment than i.v. Further… Expand
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Platinum distribution inintraperitoneal tumors afterintraperitoneal cisplatin treatment
Pharmacokinetics and tissue distribution of cisplatin in nude mice: platinum levels and cisplatin-DNA adducts
Optimisation of intraperitoneal cisplatin therapy with regional hyperthermia in rats.
Cellular pharmacokinetics of carboplatin and cisplatin in relation to their cytotoxic action.
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