Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy.

Abstract

Chemotherapy i.p. is increasingly being tested as a treatment modality for cancer limited to the peritoneal cavity. We have developed a rat tumor model in which penetration and distribution of cis-diamminedichloroplatinum(II) into intraperitoneal tumors have been studied. The platinum concentration in intraperitoneal tumor nodules, measured by two… (More)

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@article{Los1989DirectDO, title={Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy.}, author={Gerrit Los and Peter H. A. Mutsaers and W J Van der vijgh and Glenn S. Baldew and Peter W de Graaf and J G Mcvie}, journal={Cancer research}, year={1989}, volume={49 12}, pages={3380-4} }