Direct determination of the primary binding site of cisplatin on cytochrome C by mass spectrometry.

Abstract

Protein-cisplatin interactions lie at the heart of both the effectiveness of cisplatin as a therapeutic agent and side effects associated with cisplatin treatment. Because a greater understanding of the protein-cisplatin interactions at the molecular level can inform the design of cisplatin-like agents for future use, mass spectrometric determination of the… (More)
DOI: 10.1016/j.jasms.2009.02.013

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