Direct determination of free thyroxin in undiluted serum by equilibrium dialysis/radioimmunoassay.

@article{Nelson1988DirectDO,
  title={Direct determination of free thyroxin in undiluted serum by equilibrium dialysis/radioimmunoassay.},
  author={John C. Nelson and Ruggero Tomei},
  journal={Clinical chemistry},
  year={1988},
  volume={34 9},
  pages={1737-44}
}
We have designed a re-usable dialysis cell and a complex dialysis buffer, with which undiluted serum samples can be dialyzed with minimal changes in their serum matrix. Dialysate thyroxin (free T4) is then measured by a sensitive RIA for T4. The range of reportability was 2-128 ng/L, the normal range was 8-27 ng/L, and the interassay CV was 7%. Free T4 concentrations in various disorders were as follows: hyperthyroidism, 32-478 ng/L; in both excess thyroxin-binding globulin (TBG) and familial… CONTINUE READING

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