Direct determination of alkyl phosphates in human urine by liquid chromatography/electrospray tandem mass spectrometry.

@article{Hernandez2002DirectDO,
  title={Direct determination of alkyl phosphates in human urine by liquid chromatography/electrospray tandem mass spectrometry.},
  author={Felix Hernandez and Juan Vicente Sancho and {\'O}scar J Pozo},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2002},
  volume={16 18},
  pages={1766-73}
}
A novel and rapid procedure based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the determination of dialkyl phosphates (metabolites of organophosphorus pesticides) in human urine has been developed. After addition of 40 mM tetrabutylammonium acetate, 10 microL of urine sample were directly injected into the LC/MS/MS system. The method was validated yielding calibration curves with correlation coefficients greater than 0.997 and repeatability coefficient of variation (CV… CONTINUE READING

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