Direct determination of adamantanamine in plasma and urine with automated solid phase derivatization.

  title={Direct determination of adamantanamine in plasma and urine with automated solid phase derivatization.},
  author={F. Zhou and I. Krull and B. Feibush},
  journal={Journal of chromatography},
  volume={619 1},
  • F. Zhou, I. Krull, B. Feibush
  • Published 1993
  • Chemistry, Medicine
  • Journal of chromatography
  • A simple, highly sensitive and selective method is described for adamantanamine determination in plasma and urine by high-performance liquid chromatography with fluorescence detection. The method involved a simultaneous extraction and derivatization of biological fluids with a 9-fluoreneacetate (9-FA) solid-phase derivatization reagent. This approach eliminated tedious sample preparation steps and provided automatic derivatization with selective and efficient sample clean-up for direct… CONTINUE READING
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