Direct detection of peptides and proteins on a microfluidic platform with MALDI mass spectrometry.

@article{Yang2012DirectDO,
  title={Direct detection of peptides and proteins on a microfluidic platform with MALDI mass spectrometry.},
  author={Mian Yang and Tzu-Chiao Chao and Randall S Nelson and Alexandra Ros},
  journal={Analytical and bioanalytical chemistry},
  year={2012},
  volume={404 6-7},
  pages={1681-9}
}
The ability to detect and quantify proteins of individual cells in high throughput is of enormous biological and clinical relevance. Most methods currently in use either require the measurement of large cell populations or are limited to the investigation of few cells at a time. In this report, we present the combination of a polydimethylsiloxane-based microfluidic device to a matrix-assisted laser desorption ionization time-of-flight mass spectrometer (MALDI-TOF-MS) that allows the detection… CONTINUE READING

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