Direct detection of multidrug-resistant Mycobacterium tuberculosis in clinical specimens in low- and high-incidence countries by line probe assay.

@article{Johansen2003DirectDO,
  title={Direct detection of multidrug-resistant Mycobacterium tuberculosis in clinical specimens in low- and high-incidence countries by line probe assay.},
  author={Işik Somuncu Johansen and Bettina H Lundgren and Anaida Sosnovskaja and Vibeke \Ostergaard Thomsen},
  journal={Journal of clinical microbiology},
  year={2003},
  volume={41 9},
  pages={4454-6}
}
The INNO-LiPA Rif.TB assay is designed for the detection of rpoB gene mutations causing rifampin resistance in isolates. We applied the method directly to 60 Lithuanian and Danish clinical specimens to detect rifampin resistance rapidly. Results were obtained in 78.3% of clinical specimens, and all were concordant with those obtained by BACTEC 460. The assay could have major impact on the management of multidrug-resistant tuberculosis. 

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Evaluation of the INNO-LiPA Rif. TB assay, a reverse hybridization assay for the simultaneous detection of Mycobacterium tuberculosis complex and its resistance to rifampin

R. Rossau, H. Traore, +4 authors F. Portaels
Antimicrob. Agents Chemother • 1997

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