Direct demonstration of the active salvage of preformed purines by murine tumors.

Abstract

The purine de novo biosynthetic pathway has become a target for chemotherapeutic agents and because of the possible contribution of the salvage of extracellular purines to cellular purine pools an examination of the ability of mouse tumors in vivo to exploit the salvage pathways was undertaken. Our data reveal that circulating radiolabeled preformed purines… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.