Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells.

@article{Tsukahara1994DirectDO,
  title={Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells.},
  author={Hirokazu Tsukahara and Dmitri V. Gordienko and B Tonshoff and Marie C. Gelato and Michael S. Goligorsky},
  journal={Kidney international},
  year={1994},
  volume={45 2},
  pages={598-604}
}
Several lines of evidence indicate that insulin-like growth factor-I (IGF-I) is a potent mediator of vasodilation. To elucidate the mechanism and site of action of IGF-I, we performed continuous monitoring of nitric oxide (NO) release from endothelial cells using a highly-sensitive amperometric NO-sensor. Two types of cultured cells were used: human umbilical vein endothelial cells and immortalized rat renal interlobar artery endothelial cells. In separate experiments, [Ca2+]i changes in… CONTINUE READING
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