Direct decarboxylation of 5-carboxylcytosine by DNA C5-methyltransferases.


S-Adenosylmethionine-dependent DNA methyltransferases (MTases) perform direct methylation of cytosine to yield 5-methylcytosine (5mC), which serves as part of the epigenetic regulation mechanism in vertebrates. Active demethylation of 5mC by TET oxygenases produces 5-formylcytosine (fC) and 5-carboxylcytosine (caC), which were shown to be enzymatically… (More)
DOI: 10.1021/ja5019223


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@article{Liutkeviit2014DirectDO, title={Direct decarboxylation of 5-carboxylcytosine by DNA C5-methyltransferases.}, author={Zita Liutkevi{\vc}iūtė and Edita Kriukienė and Janina Li{\vc}ytė and Milda Rudytė and Giedrė Urbanavi{\vc}iūtė and Saulius Klima{\vs}auskas}, journal={Journal of the American Chemical Society}, year={2014}, volume={136 16}, pages={5884-7} }