Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line.

@article{Yukawa2012DirectCO,
  title={Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line.},
  author={Hiroshi Yukawa and Satoru Ishikawa and Takashi Kawanishi and Makoto Tamesada and Hironori Tomi},
  journal={Biological & pharmaceutical bulletin},
  year={2012},
  volume={35 7},
  pages={1014-21}
}
Lentinula edodes mycelia (L.E.M.) is a dried powder extracted from shiitake mushrooms (Lentinula edodes). We previously demonstrated that it has immunomodulatory effects. In this paper, the direct cytotoxic effects of the polysaccharide-rich fraction of L.E.M. (L.E.M. ethanol precipitate; LEP) on HepG2 human hepatocellular carcinoma (HCC) cells were investigated. LEP directly killed the HepG2 cells efficaciously, but had only minor effects on normal rat hepatocytes and normal mouse dermal cells… CONTINUE READING
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