Direct-current electrical field guides neuronal stem/progenitor cell migration.

  title={Direct-current electrical field guides neuronal stem/progenitor cell migration.},
  author={Lei Li and Youssef Hanna El-Hayek and Baosong Liu and Yonghong Chen and Everlyne Gomez and Xiaohua Wu and Ke Ning and Lijun Li and Ning Chang and Liang Zhang and Zhengguo Wang and Xiang Hu and Qi Wan},
  journal={Stem cells},
  volume={26 8},
Direct-current electrical fields (EFs) promote nerve growth and axon regeneration. We report here that at physiological strengths, EFs guide the migration of neuronal stem/progenitor cells (NSPCs) toward the cathode. EF-directed NSPC migration requires activation of N-methyl-d-aspartate receptors (NMDARs), which leads to an increased physical association of Rho GTPase Rac1-associated signals to the membrane NMDARs and the intracellular actin cytoskeleton. Thus, this study identifies the EF as a… CONTINUE READING
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