Direct cryocooling of naked crystals: are cryoprotection agents always necessary?

@article{Pellegrini2011DirectCO,
  title={Direct cryocooling of naked crystals: are cryoprotection agents always necessary?},
  author={Erika Pellegrini and Dario Piano and Matthew W Bowler},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2011},
  volume={67 Pt 10},
  pages={
          902-6
        }
}
Over the last 20 years cryocrystallography has revolutionized the field of macromolecular crystallography, greatly reducing radiation damage and allowing the collection of complete data sets at synchrotron sources. However, in order to cool crystals to 100 K cryoprotective agents must usually be added to prevent the formation of crystalline ice, which disrupts the macromolecular crystal lattice and often results in a degradation of diffraction quality. This process can involve the extensive… CONTINUE READING
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