Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation.

@article{Kneilling2009DirectCB,
  title={Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation.},
  author={Manfred Kneilling and Reinhard Mailhammer and Lothar H{\"u}ltner and Tanja Schoenberger and Kerstin Fuchs and Martin Schaller and Daniel Bukala and Steffen Massberg and Christian A. Sander and Heidi Braum{\"u}ller and Martin Eichner and Konrad Ludwig Maier and Rupert Hallmann and Bernd Pichler and Roland Haubner and Meinrad Gawaz and Klaus Pfeffer and Tilo Biedermann and Martin Roecken},
  journal={Blood},
  year={2009},
  volume={114 8},
  pages={1696-706}
}
Signaling through tumor necrosis factor receptor 1 (TNFR1) controls bacterial infections and the induction of inflammatory Th1 cell-mediated autoimmune diseases. By dissecting Th1 cell-mediated delayed-type hypersensitivity responses (DTHRs) into single steps, we localized a central defect to the missing TNFR1 expression by endothelial cells (ECs). Adoptive transfer and mast cell knockin experiments into Kit(W)/Kit(W-v), TNF(-/-), and TNFR1(-/-) mice showed that the signaling defect exclusively… CONTINUE READING

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