Direct coupling of the cell cycle and cell death machinery by E2F

  title={Direct coupling of the cell cycle and cell death machinery by E2F},
  author={Zaher A. Nahl{\'e} and Julia Polakoff and Ramana V. Davuluri and Mila E. McCurrach and Matthew D. Jacobson and Masashi Narita and Michael Q Zhang and Yuri A. Lazebnik and Dafna Bar-Sagi and Scott W Lowe},
  journal={Nature Cell Biology},
Unrestrained E2F activity forces S phase entry and promotes apoptosis through p53-dependent and -independent mechanisms. Here, we show that deregulation of E2F by adenovirus E1A, loss of Rb or enforced E2F-1 expression results in the accumulation of caspase proenzymes through a direct transcriptional mechanism. Increased caspase levels seem to potentiate cell death in the presence of p53-generated signals that trigger caspase activation. Our results demonstrate that mitogenic oncogenes engage a… CONTINUE READING
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New targets for E2F transcription factors

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